Unfortunately, that isn't likely to happen. Netanyahu has, to date, handled Trump deftly and Rubio's current presence in Israel seems to be aimed at offering support to the ground offensive, not opposition. I honestly have no idea what kind of backlash it would take to shake U.S. support for this genocide.
It is worth noting that Andrew Cuomo, in a desperate last-minute gamble to boost support in the NYC mayoral race, has come out against Israel. Considering that much of the attacks on Mamdani have focused on his support for Palestine (construing him as antisemitic), it's notable that other candidates also seem to think that being anti-Israel is actually the vote winner for moderates right now.
And as for the Right, it's primarily isolationism, but they certainly aren't going to favoring Palestine over Israel anytime. That's already hedged in. At the end of day, it largely goes against of the interests of every actor not aligned with Iran or seeking stability to let Israel fall in favour of Palestine. We do need that hard power when America is retreating from the region.