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Air pollution directly linked to increased dementia risk

(www.nature.com)
275 points rntn | 1 comments | 07 Sep 25 13:13 UTC | HN request time: 0s | source
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FollowingTheDao ◴[07 Sep 25 14:23 UTC] No.45158391[source]▶
In my opinion, the reason air pollution effects dementia risk is through activation of Heat Shock Proteins and I think it is the most valuable place to be investing in research.

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

https://pmc.ncbi.nlm.nih.gov/articles/PMC6163571/

replies(2): >>45158427 #>>45158452 #
hereme888 ◴[07 Sep 25 14:30 UTC] No.45158452[source]▶
It seems to be multifactorial. Per an OpenEvidence query, which cites many recent studies:

"In summary, the mechanism of PM2.5-induced brain damage involves entry via the olfactory system and BBB, activation of glial cells, neuroinflammation, oxidative stress, BBB disruption, and downstream neurodegenerative changes."

replies(1): >>45160249 #
FollowingTheDao ◴[07 Sep 25 17:28 UTC] No.45160249[source]▶
Heat Shock Proteins affect the function of all of those systems . Put that into OpenEvidence...

Learn about biology instead of relying on simple searches for you answers.

replies(1): >>45162555 #
1. hereme888 ◴[07 Sep 25 21:57 UTC] No.45162555{3}[source]▶
Learn about biology? lol, idk how much more to do so. What's your professional training background?