> a reminder about the goal of this project. The web is not print. Webpages are not books. Therefore, the goal of Tufte CSS is not to say “websites should look like this interpretation of Tufte’s books” but rather “here are some techniques Tufte developed that we’ve found useful in print; maybe you can find a way to make them useful on the web”.
Reading this I think an interesting alternative approach could to be apply Tufte's principles to a CMS rich text field editor or to a frontend templating library - something that generates HTML - rather than focusing purely on the CSS side. This & selecting some less print-oriented type.