By now, the downsides are well-known, but I think Python's implementation did a few things that made it particularly unpleasant to use.
There is the usual "colored functions" problem. Python has that too, but on steroids: There are sync and async functions, but then some of the sync functions can only be called from an async function, because they expect an event loop to be present, while others must not be called from an async function because they block the thread or take a lot of CPU to run or just refuse to run if an event loop is detected. That makes at least four colors.
The API has the same complexity: In JS, there are 3 primitives that you interact with in code: Sync functions, async functions and promises. (Understanding the event loop is needed to reason about the program, but it's never visible in the code).
Whereas Python has: Generators, Coroutines, Awaitables, Futures, Tasks, Event Loops, AsyncIterators and probably a few more.
All that for not much benefit in everyday situations. One of the biggest advantages of async/await was "fearless concurrency": The guarantee that your variables can only change at well-defined await points, and can only change "atomically". However, python can't actually give the first guarantee, because threaded code may run in parallel to your async code. The second guarantee already comes for free in all Python code, thanks to the GIL - you don't need async for that.