If the first item isn't "whitelist JS", you're doing it wrong. So many problems arise from letting any site run programs on your computer that it's best to reserve the privilege to the most trusted of sites.
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If they are doing meaningful review, I question how much they actually get done in life.
I still use it honestly, but I'll need to move on at some point - not just because it's MV2-only, but also I've found a way in which uMatrix can be bypassed if a website were to specifically target it. (It doesn't affect uBlock Origin, although I haven't tested the Lite MV3 version.)