New research reveals horse-drawn wagon engineering gains slowing, travel at speeds beyond 12mph unlikely.
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We need to remember that our bodies are evolutionarily optimized for getting to childbearing years, and then living long enough to get our children to a point where they can be independent. After that there are really no evolutionary pressures keeping us around.
Untangling all that and re-engineering ourselves (biologically) to overcome that is probably a pretty monumental task; starting from scratch with something simpler (and perhaps non-biological) might be easier, with sufficiently advanced technology.