My wife went through semi-expetimental therapy (at that time) for her MS. It was tough but ultimately a net benefit.
It all depends on what is at stake - I would consider Ozempic for some weight loss but prefer, for now, go for no sugar and moderate portions. This is not life changing for me so I indeed prefer people who will benefit way more from it to go first.
The reason you might think twice about going first is for that exact reason, there are risks. Plenty of blind people would prefer to stay as they are than be left worse off to a greater degree after undergoing the implant.
And as for which state one wants to be in, this is a matter of personal choice. I know that I will commit suicide right after I get a diagnosis of, say, Alzheimer's (after cleaning up my stuff). If I went blind and had a reasonable chance to get back to sight, then I would also go for it, weighing the risks.
It all boils down to what someone perceives as "better"