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abeppu ◴[] No.45027823[source]
> When he and his colleagues looked at the individuals’ immune cells, they could see encounters with all sorts of viruses—flu, measles, mumps, chickenpox. But the patients had never reported any overt signs of infection or illness.

Given that the article goes on to talk about mild persistent inflammation, is it possible that these individuals are sometimes asymptomatic but still capable of carrying/transmitting viruses at least temporarily? The article talks about potentially immunizing healthcare workers during a future pandemic, but if this was just allowing people to never develop symptoms (and not have to leave work) while having low-grade infections, would we accidentally create a work-force of Typhoid Marys?

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etiam ◴[] No.45031369[source]
Excellent point, and it seems plausible in my opinion.

https://www.frontiersin.org/journals/immunology/articles/10....

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1. etiam ◴[] No.45031558[source]
Oh, and it's probably worthwhile pondering what the viruses will do if this mechanism comes into widespread use.

While I was looking for the reference above this also came up:

https://www.sciencedaily.com/releases/2020/02/200210144854.h...

when bat cells quickly release interferon upon infection, other cells quickly wall themselves off. This drives viruses to faster reproduction

Quite a way from whole-animal physiology in the referenced research, by all means, but it's a fair point, right.