One universal antiviral to rule them all?

It was already invented [0], but the patents were bought by a small company in New Zealand (some kind of big pharma shell company?) who isn't seriously developing it and now appears to be defunct.

[0] https://en.wikipedia.org/wiki/DRACO

Doesn't sound all the bad from the linked wiki:

""" In March 2024 Kimer Med announced it has signed a contract valued at up to USD$750,000 (NZD$1.3 million) with Battelle Memorial Institute (Battelle), the world’s largest independent, nonprofit research and development organization. The contract is focused on the discovery and development of new antiviral drug candidates for the treatment of alphaviruses. """

The cynical part of me wonders: if this has been a promising approach for 10+ years, why weren't they able to secure VC funding years ago (or nonprofit biomedical research funding from places like the Gates Foundation that care a lot about infectious disease)?

This. Claims of a universal antiviral are as old as western medicine itself. Literally the only reason anyone knows what the Hippocratic oath is is because Hippocrates was already famous at the time for promoting elderberry as the universal antiviral.

Both are broad spectrum antivirals, but completely different mechanism.

DRACO "is a chimeric protein with one domain that binds to viral double stranded RNA (dsRNA) and a second domain that induces apoptosis when two or more DRACOs crosslink on the same dsRNA." (Ridder et al 2011). This article is about packaging mRNA for a set of 10 interferon-stimulated genes that express multiple proteins that target various stages of viral replication.

Because curing profits isn't really on their priority list at all, it's all virtue posturing.

There’s alot of promising approaches and investments made.

The miracle of the mRNA covid vaccine and the use of that framework to treat cancer is a good example.

As we wind down research in the US, there will be lots of churn as the market finds new approaches to development.

Definitely! However, the parent made it sound like the pharma industry put it in a giant warehouse next to the arch of the covenant

My understanding is that the _concept_ of a virus wasn't even established until the late 19th century, because we first needed the germ theory, and then we needed to understand bacteria well enough to have a filter whose pores were known to be smaller than bacteria could pass through, but which some _other_ infection agent could still pass through.

https://en.wikipedia.org/wiki/History_of_virology#Discovery

Hippocrates could recommend elderberry for a bunch of ailments, but he didn't have the concept of a "universal antiviral".

Did Hippocrates know the difference between viral and bacterial infections?