I'm using docker compose to include some supporting containers like go-vod (for hardware transcoding), another nextcloud instance to handle push notifications to the clients, and redis (for caching). I can share some more details, foibles and pitfalls if you'd like.
I initiated a rescan last week, which stacks background jobs in a queue that gets called by cron 2 or 3 times a day. Recognize has been cranking through 10k-20k photos per day, with good results.
I've installed a desktop client on my dad's laptop so he can dump all of the family hard drives we've accumulated over the years. The client does a good job of clearing up disk space after uploading, which is a huge advantage in my setup. My dad has used the OneDrive client before, so he was able to pick up this process very quickly.
Nextcloud also has a decent mobile client that can auto-upload photos and videos, which I recently used to help my mother-in-law upload media from her 7-year-old iPhone.