I did many of my own experiments with templates that are native JS with no compile step, and reached basically the same conclusion as this post. Use tagged templates and keep it simple. My angle was server-focused, with async bits in a template doing automatic streaming while server rendering with them. Works super well and it takes so little code to achieve. Check it out if you're interested: https://www.hyperspan.dev/ or the CodeSandbox demo: https://7lpdpl.csb.app/