Aging-related inflammation is not universal across human populations

from what I have read, it appears that while the weight loss plays a role that the anti-inflammatory effects exist independently of that as well.

I am cheating as I don't want to do a lot of writing to summarize so I just had chatGPT summarize for me:

Mechanisms Beyond Weight Loss Direct Action on Immune Cells:

GLP-1 receptors are found on several immune cells (like macrophages, T cells, and dendritic cells).

Activation of these receptors can suppress pro-inflammatory cytokines (like TNF-α, IL-6) and enhance anti-inflammatory ones (like IL-10).

Reduction in Systemic Inflammation:

Studies show reduced levels of C-reactive protein (CRP) and interleukins in patients taking GLP-1s, even when controlling for weight loss.

In diabetic patients, GLP-1s can reduce oxidative stress and endothelial inflammation, improving cardiovascular outcomes.

Improved Gut Barrier Function:

GLP-1s may reduce gut permeability ("leaky gut"), which helps prevent the translocation of inflammatory endotoxins (like LPS) into circulation.

Neuroinflammation:

In animal models, GLP-1s cross the blood-brain barrier and have shown protective effects against neuroinflammation, relevant in diseases like Alzheimer’s and Parkinson’s.