This means spammers, right?
That's another name for spam.
The fact that you have to frame it your way speaks mostly to the fact that apparently your income depends on spam being seen as acceptable and not a scourge to humanity. But that's just my perspective...
Define "low quality" and "not liked". Each person will classify a given message differently. At least in the general case it's hardly realistic to expect a sender to classify a message from the perspective of a specific recipient prior to sending it.
On the other hand, it is reasonable to expect addresses to be acquired via legitimate means (ie collected only with the consent of the recipient) and to cease attempts at contact when requested. That's essentially the boundary between reasonable conduct and harassment.
Me personally I won't give a pass to business with an unsubscribe link, I have extreme disgust that we're in some make-believe pretend world that I asked for this in the first place