Lots of reads and writes in the original NES just toggled voltages on a line somewhere, and then what happened, happened. You got the effect you wanted by toggling those voltages in a very controlled manner lock-stepped with the signal indicating the behavior of the CRT blanking intervals. Some animations in Super Mario Bros 3 involved toggling a RAM mux to select from multiple banks of sprite data so that when the graphics hardware went to pull sprites, it'd pull them from an entirely different chip with slight variations in their look. And since the TV timing mattered, they had to release different software for regions with NTSC and PAL TVs since those TVs operate with different refresh rates and refresh rate was the clock that drove the render logic.
It was a wild time.