Biomolecular shifts occur in our 40s and 60s (2024)

I'd posit that another significant decline in moving occurs in the sixties when many go in rent.

Not sure if the biological clock is cause of abrupt changes or rather our scheduled lives. So, no significant changes from the sixties on? Then what's the genetic function of those programmations?

People who reach old age (100+) are mostly also comparatively healthy.

I'm in my mid 40s and in the best shape of my life, lots of energy, aches and pains from my late 30s have all disappeared, to get there it took diet and exercise changes that were surprisingly modest. For me it was mostly weights, a little bit of cardio, and cutting back on my worst episodes of caloric excess.

I have friends who didn't do any diet and exercise interventions, and are starting to look like hell and complain about the "inevitable" consequences of aging.

And then there are those jacked dudes in their 70s who are hitting the gym 5 times a week, I can only aspire to be as healthy as them at their age.

Use it (with proper care and feeding) or lose it.

I'm 55 and found - much to my surprise - that 12 months of carefully progressively and intense running training has improved me from a slow plodder (jogging 5km a couple of times a week) to on track for a 3 hour marathon later this year. Along the way, I'm back to the weight I had in my early 20s, but now also am a lot faster and with way more endurance.

Of course, at 55, I now need to be more careful now about not getting injured. Which means being disciplined about stretching, strength training and recovery. Things I never needed to worry about when I was younger.

So absolutely:

> Use it (with proper care and feeding) or lose it.