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Biomolecular shifts occur in our 40s and 60s (2024)

(med.stanford.edu)
170 points fzliu | 2 comments | 27 Jun 25 03:51 UTC | HN request time: 0.547s | source
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nakedneuron ◴[27 Jun 25 06:19 UTC] No.44394139[source]▶
Truth is many people also stop moving (exercising) significantly in their forties (reason being probably sitting lifestyle promotes posture and fascia degradation which makes moving less and less enjoyable).

I'd posit that another significant decline in moving occurs in the sixties when many go in rent.

Not sure if the biological clock is cause of abrupt changes or rather our scheduled lives. So, no significant changes from the sixties on? Then what's the genetic function of those programmations?

People who reach old age (100+) are mostly also comparatively healthy.

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safety1st ◴[27 Jun 25 07:45 UTC] No.44394645[source]▶
Without writing a book about it I'll just say that I think the most important thing is people shouldn't look at this info and conclude that their body's going to fall apart no matter what.

I'm in my mid 40s and in the best shape of my life, lots of energy, aches and pains from my late 30s have all disappeared, to get there it took diet and exercise changes that were surprisingly modest. For me it was mostly weights, a little bit of cardio, and cutting back on my worst episodes of caloric excess.

I have friends who didn't do any diet and exercise interventions, and are starting to look like hell and complain about the "inevitable" consequences of aging.

And then there are those jacked dudes in their 70s who are hitting the gym 5 times a week, I can only aspire to be as healthy as them at their age.

Use it (with proper care and feeding) or lose it.

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matthewdgreen ◴[27 Jun 25 07:59 UTC] No.44394738[source]▶
I also felt this way in my mid-40s. I still feel this way. But then after a lifetime of perfect vision, one day I was reading a book and noticed that everything was a little blurry. Now I need reading glasses. Not a big deal! I’m doing fine! But a gentle reminder that all the diet and CrossFit in the world isn’t going to save you from a (hopefully) gentle and inevitable decay ;)
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mhfu ◴[27 Jun 25 08:51 UTC] No.44395063[source]▶
I mean, of course exercise isn't going to fix your vision. But if your vision is going to degrade, you can still choose if you want to live as a fit and healthy person who needs reading glasses, or as a person who has aches all over, is in bad shape, feels tired and like shit all the time, and on top of all that needs reading glasses.
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gosub100 ◴[27 Jun 25 14:37 UTC] No.44397139[source]▶
I feel like shit when I exercise, and on top of that it's extremely mind-numbing. On par with watching paint dry.
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1. safety1st ◴[27 Jun 25 14:51 UTC] No.44397234[source]▶
I relate somewhat to this and those were two reasons I didn't exercise for a long time.

1) Feeling like shit: I found out that when I felt like shit it was a sign that I was going too hard. After falling off the wagon a few times because my workouts were so unpleasant, I decided that instead of quitting, this time I would keep going to the gym but just exercise like a pussy. Turns out light to moderate exercise is dramatically better than no exercise. Exercising like a pussy has eliminated all the aches and pains I used to have, fixed a wrist that was developing carpal tunnel, fixed a bad knee, lowered my blood pressure by 12 points, etc.

2) For me cardio is mind numbing, but weight training isn't bad. I mean weight training is basically doing a set, then sitting around for a few minutes messing with your phone or listening to a podcast or reading a book or whatever, then repeating. This is why most of my exercise is weight training, and my cardio sessions are 20min max. It works just fine, you get a ton of cardio from doing compound lifts. Also my gym has a jacuzzi where I can zone out after my workout and listen to podcasts, this turns the gym into the highlight of my day tbh.

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2. nakedneuron ◴[27 Jun 25 17:54 UTC] No.44398836[source]▶
"Pussy exercise" sounds like you're doing everything right for building your fascia!

As fascia stabilizes joints it explains your joints getting better. Focus on soft, bouncing movements if you want to regain, enhance or simply conserve fascia tissue.

Also, with time, it enables you to do with heavier weights and plainly brings back joy to moving. All the best.