The abstract brings up SSTOs, but has there been anything in recent invention that will make them anything other than the white whale people have been chasing since forever?
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SSTO is just marginally possible, if it is possible you need exotic materials and engines and you're never going to get a good payload fraction and adding wings, horizontal takeoff, horizontal landing and such just makes it worse. The one good thing about it is that you get closer to "aircraft-like operations" because in principle you can inspect it, refill it, and relaunch it -- whereas something like the STS or Falcoln 9 or Starship will require stacking up multiple parts for each launch.
My guess is aerospikes are making a comeback though because of interest in hypersonic weapons system. I could also see them being useful for the second stage of something like Starship which mostly operates at high altitudes but has to land at low altitudes. There are a lot of other technical problems, like the thermal management system, which really have to be solved before worrying about that optimization.
Similarly, I assume there are valid reasons SpaceX has chosen not to use aerospike Raptors, especially given their well-earned reputation for innovating things everyone else swore couldn't be done. If even they haven't been able to make it work, that's a strong data point as to the state of the art.
Sure, they talk about Mars, and in-space refueling seems radical, but they've yet to succeed at doing anything radical... yet.
Rumor has it they were struggling with the payload fraction w/ the first generation of Starship and they switched to a second generation that struggles with blowing up. A big advantage of the two-stage architecture is that you can develop the two stages independently. Presumably they will eventually get Starship to orbit and bring it home, they will have plenty of time to improve it get the payload fraction up just as they did with F9.
Falcon 9 was a highly competitive rocket without reuse. If they didn't get reuse to work it would have been a successful project. Reuse of the first stage was a huge cost optimization that put it in a class by itself -- but they they did it radically reused risks.
Contrast that to the X-33 which would have required a large number of new technologies to all work to fly at all.
Fixed-cost pricing was also a radical innovation because it drove SpaceX to do everything it could to lower costs. It was known for a long time that reusing (only) the first stage was a good path to lower costs, the SpaceX business model rewarded them for doing it.
SpaceX is highly technically innovative but it's been so successful because technical innovation has been centered around cost reduction and practicality, not chasing high performance for the sake of high performance.
The SpaceX model might need change to get to Mars because of latency. You can launch a Starship to LEO, have it blow up, and launch another one in a few weeks. If a Starship fails to land on Mars, however, you have to wait another two and a half years to try again. Similarly, SpaceX runs everything by remote control from mission control which is great in LEO but to stick a landing on Mars you need something that flies autonomously.
I don't believe the stage landings are remote controlled. I've seen several times where they lost contact with the craft but it landed safely.
It would also be a weird choice because radio connections are way too unreliable to be a single point of failure.