Biomolecular shifts occur in our 40s and 60s (2024)

That's quite well-known already. The real question here: how do we stop these shifts from happening?

When I look into my biohacker bubble, the answer might be: enough sleep, regular workout routine with HIIT, healthy whole foods, no alcohol, socializing

and yet none of that makes even a dent

For you personally, maybe not, but statistically yes it does.

There are populations that consistently outlive and the only other thing I would add is stress removal in the form of relatively simple life styles.