Biomolecular shifts occur in our 40s and 60s (2024)

That's quite well-known already. The real question here: how do we stop these shifts from happening?

When I look into my biohacker bubble, the answer might be: enough sleep, regular workout routine with HIIT, healthy whole foods, no alcohol, socializing

and yet none of that makes even a dent

For you personally, maybe not, but statistically yes it does.

There are populations that consistently outlive and the only other thing I would add is stress removal in the form of relatively simple life styles.

At some point you have to wonder about the costs. Denying yourself everything that's nice and pleasant, and exercising constant, total active control over yourself sure might prolong your life, but what's the point?

The thing is, drinking to excess, smoking, eating ‘badly’ just aren’t pleasures at all if you don’t do them all the time. It’s hard to take the perspective, but there is more to life!

Right, but that's the other extreme. Then there's everything in the middle, and most of that, unfortunately, do not form a kind of "healthy lifestyle" that has a chance to confer longevity benefits. So when people say, "just have a good diet and exercise regularly and sleep long enough and such" - it's a bit of a lie, because to do enough of these things to matter, you might be required to sacrifice the very things you value in life the most.

And I mean here both sacrifice the things you hold dear directly, or indirectly - which for us here is predominantly our careers and places of living.

Exaggerating a little bit to underscore the point: I could likely add years to my QALY lifespan if I moved to countryside, picked up more manual labor that required me to move my whole body, and went hiking in between going to the gym -- but, the things I value are found in cities, the work I like is white-collar, I hate hiking, and I also have people I love to support and lifespan-friendly labor generally doesn't pay enough.