Biomolecular shifts occur in our 40s and 60s (2024)

That's quite well-known already. The real question here: how do we stop these shifts from happening?

When I look into my biohacker bubble, the answer might be: enough sleep, regular workout routine with HIIT, healthy whole foods, no alcohol, socializing

and yet none of that makes even a dent

For you personally, maybe not, but statistically yes it does.

There are populations that consistently outlive and the only other thing I would add is stress removal in the form of relatively simple life styles.

At some point you have to wonder about the costs. Denying yourself everything that's nice and pleasant, and exercising constant, total active control over yourself sure might prolong your life, but what's the point?