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Biomolecular shifts occur in our 40s and 60s (2024)

(med.stanford.edu)
170 points fzliu | 3 comments | 27 Jun 25 03:51 UTC | HN request time: 0.407s | source
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nakedneuron ◴[27 Jun 25 06:19 UTC] No.44394139[source]▶
Truth is many people also stop moving (exercising) significantly in their forties (reason being probably sitting lifestyle promotes posture and fascia degradation which makes moving less and less enjoyable).

I'd posit that another significant decline in moving occurs in the sixties when many go in rent.

Not sure if the biological clock is cause of abrupt changes or rather our scheduled lives. So, no significant changes from the sixties on? Then what's the genetic function of those programmations?

People who reach old age (100+) are mostly also comparatively healthy.

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safety1st ◴[27 Jun 25 07:45 UTC] No.44394645[source]▶
Without writing a book about it I'll just say that I think the most important thing is people shouldn't look at this info and conclude that their body's going to fall apart no matter what.

I'm in my mid 40s and in the best shape of my life, lots of energy, aches and pains from my late 30s have all disappeared, to get there it took diet and exercise changes that were surprisingly modest. For me it was mostly weights, a little bit of cardio, and cutting back on my worst episodes of caloric excess.

I have friends who didn't do any diet and exercise interventions, and are starting to look like hell and complain about the "inevitable" consequences of aging.

And then there are those jacked dudes in their 70s who are hitting the gym 5 times a week, I can only aspire to be as healthy as them at their age.

Use it (with proper care and feeding) or lose it.

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1. globular-toast ◴[27 Jun 25 08:47 UTC] No.44395037[source]▶
> those jacked dudes in their 70s

Those dudes are almost certainly on some kind of testosterone. It obviously works for some. Arnold Schwarzenegger, for example, has almost certainly been "supplementing" for close to 60 years now. The trouble is we don't know for sure what these individuals have been doing, nor do we know the effects of such "cocktails" on the population at large.

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2. wonderwonder ◴[27 Jun 25 12:00 UTC] No.44396087[source]▶
You are 100% right, I don't see it as a negative though. Almost everyone in their 70's is on some form of medication. I'm mid 40's and have been on testosterone for ~4 years. Best shape of my life both physically and blood work wise. Testosterone (at sane doses), GLP-1s, etc are miracle drugs that dramatically improve ones' quality of life. While you are absolutely correct that "those dudes are almost certainly on some kind of testosterone" I see it as very positive.

My FIL, in his 70's is on a cocktail of pain killers, blood pressure medication and a hundred other things and has a hard time even getting out of a pool. I'll take being an old jacked dude over that any day

3. razakel ◴[27 Jun 25 12:10 UTC] No.44396144[source]▶
>Arnold Schwarzenegger, for example, has almost certainly been "supplementing" for close to 60 years now.

He's admitted it and advised younger bodybuilders not to.

Having access to the best sports medicine doctors in the world means you too can look great at nearly 80.