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Biomolecular shifts occur in our 40s and 60s (2024)

(med.stanford.edu)
170 points fzliu | 4 comments | 27 Jun 25 03:51 UTC | HN request time: 0.406s | source
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nakedneuron ◴[27 Jun 25 06:19 UTC] No.44394139[source]▶
Truth is many people also stop moving (exercising) significantly in their forties (reason being probably sitting lifestyle promotes posture and fascia degradation which makes moving less and less enjoyable).

I'd posit that another significant decline in moving occurs in the sixties when many go in rent.

Not sure if the biological clock is cause of abrupt changes or rather our scheduled lives. So, no significant changes from the sixties on? Then what's the genetic function of those programmations?

People who reach old age (100+) are mostly also comparatively healthy.

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1. globular-toast ◴[27 Jun 25 08:10 UTC] No.44394817[source]▶
If this were true then we'd see that people with active jobs like builders, mechanics, cleaners etc. would have different outcomes. I think many people here who have never done a physical job in their lives would be shocked at how physically demanding these jobs are. Going to the gym a few times a week does not compare to all day, every day on your feet for decades.
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2. adrianN ◴[27 Jun 25 08:52 UTC] No.44395071[source]▶
Adequate rest is quite important to prevent the kind of injuries people in physical jobs get.
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3. amunozo ◴[27 Jun 25 09:45 UTC] No.44395356[source]▶
Not only that, but in my experience most physical workers drink a lot and eat poorly. Not all, for sure, but it's pretty common at least in Spain. But rest is extremely important.
4. mattlondon ◴[27 Jun 25 11:50 UTC] No.44396027[source]▶
Indeed - and I would argue that despite that a lot of comments here and elsewhere anecdotally say that physical exercise helps to prevent signs of aging, some of these people who spend their entire time doing hard physical work do not look younger or healthier. They often look like they've lived pretty hard lives with really battered looking complexions and wrinkles etc - they almost certainly do NOT look "youthful" or "young for their age" - the opposite in fact, at least in my experience.

We in this industry live in quite a bubble in many ways. One of them is we get to chose when we go outside and exercise (mostly), but if you're a builder or a farmer or whatever you are usaully out there doing things, rain or shine.