About 10-15 years ago I played a game on Windows system and was dual booting to Linux.
I made about 100-200 save files in a game, so opening a screen with list of saves took about 10 seconds.
But when I used the same save folder in the same game installed under wine in Linux, its loading screen took half the time. Even though NTFS is not native for Linux. I have no idea why. Windows was without antivirus software.