Autoconf is the prime example of easy vs simple.
It looks easy on the surface to roll down support for any kind of operating system there is, based on auto-detection and then #if HAVE_THIS or #if HAVE_THAT, but it breaks in ways that maybe really hard to untangle later.
I'd rather have a limited set set of configurations targeting specific platforms/flavors, and knowing that no matter how I compile it, I would know what is `#define`-d and what is not, instead of guessing on what the "host" might have.