I have been trying for years to fined a way to use it for mathematics and physics - with the former being more of a focus and didn't really get anywhere. For definitions it works, but it's quite hard to write proofs in a way where there is a short obvious memorization based answer. Either you spend far too much time on a card or the card gives you too much information so you don't really test the knowledge.
I also tried it for computer shortcuts - it seems to me that they are really useful only when part of the muscle memory - so practicing them works better then memorization.