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Baby is healed with first personalized gene-editing treatment

(www.nytimes.com)
1167 points jbredeche | 1 comments | 15 May 25 18:06 UTC | HN request time: 0s | source
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palisade ◴[16 May 25 05:32 UTC] No.44002113[source]▶
Does this mean when they grow up, their own offspring will also have this defect and require a correction? And, if so, does this mean it is now introducing this defective gene into our gene pool?

I know this is an issue with caesarean section. It is becoming more prevalent because those who require it are surviving, making it more likely to happen in their offspring.

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foreigner ◴[16 May 25 07:33 UTC] No.44002703[source]▶
We get half of our genes from each of our parents. So unless this person has the extremely unlikely misfortune of partnering with someone else with the same rare mutation, their offspring would only have a 50/50 chance of inheriting their copy of this gene. There are also medical procedures (PGD) to bring that chance to virtually 0%.
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1. Sammi ◴[16 May 25 08:21 UTC] No.44002976[source]▶
Also parents who are both carriers have a 25% chance of making a sick child, a 25% chance of making a non carrier and non sick child, and a 25%+25% chance of making non sick yet carrier child. So they already have a 50% chance of making children who'll survive and yet be carriers of the disease. I guess this will increase this to 75%. But you have to evaluate this in connection with the rapid increases in genetic treatment options, which decreases the issues.