Yes, that's why all the cool kids switched to tmux 17 years ago. The only argument the screen camp had was "no serial port support in tmux". To which we answered something about a smaller more modern code base...
I haven’t done serial port stuff in many years, so I ask this in ignorance and I give you permission to laugh at my naïveté. Can’t you just run tip or something in a tmux or zellij window and have basically the same thing?