I know Jane Street love OCaml, but you have to wonder how much it's cost them in velocity and maintenance. This is a quant firm blogging about a programming language they're the most famous user of.
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But being outside of the mainstream may mean you need to occasionally debug more esoteric stuff: https://gallium.inria.fr/blog/intel-skylake-bug/ I'm sure Jane Street can afford doing that, but I'm not so sure if a small team can.
Because despite them being very open about it, no one else does it, and every distinguished engineer who pushes a weird tech choice will justify and defend it.