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Tumor-derived erythropoietin acts as immunosuppressive switch in cancer immunity

(www.science.org)
140 points bookofjoe | 2 comments | 25 Apr 25 14:42 UTC | HN request time: 0s | source
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mariusor ◴[25 Apr 25 18:04 UTC] No.43796740[source]▶
Let me guess, this research was sponsored by Lance Armstrong?
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hinkley ◴[25 Apr 25 18:44 UTC] No.43797186[source]▶
Huh. I assumed this was going to be a collision of acronyms but erythropoietin is the same EPO used medicinally to treat anemia and abused by several generations of endurance athletes (complications include strokes and heart attacks from blood clot).

It’s a stress-signaling hormone produced by the kidneys when they detect hypoxia and triggers more red blood cell production in bone marrow.

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mariusor ◴[25 Apr 25 19:58 UTC] No.43797940[source]▶
What makes this mildly funny, though I admit in quite poor taste, is the fact that Armstrong did indeed suffer of cancer to which he lost a testicle before his comeback to win multiple Tour de France back to back. So theoretically his EPO positive results could be attributed to those tumors producing it, if this research is to be believed. Maybe not all of the times though.
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1. jamesliudotcc ◴[26 Apr 25 03:12 UTC] No.43800588[source]▶
Or, consider that the causation could have been the other way around. The EPO could have made him more susceptible to cancer.

There is a mountain of evidence that the drug cheating was systematic. You can read The Secret Race, or draw your own conclusions from the $5 million false claims act settlement.

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2. mariusor ◴[26 Apr 25 07:26 UTC] No.43801603[source]▶
You know that I was only joking right? The man admitted all his abuse on day time TV.