Adipose tissue retains an epigenetic memory of obesity after weight loss

The more you research/learn about obesity, the worse it is, much like smoking. One of the most depressing stats is that dieting does not get easier with time. The probability of eventually regaining all the weight eventually converges to 100%. Even if you're successful for 2 years, people still regain by year 4, 5, etc. The body never resists trying to regain the weight. GLP-1 drugs are the best hope yet.

> One of the most depressing stats is that dieting does not get easier with time.

Yeah, I've tried several times under medical control.

I kept asking my supervising doctor: "When is the constant hunger going to get better?" And the answer was always in the range of a few weeks to several months. But that moment never came... never!

And, in the end, all the kilograms I had lost along the route always found their way back home, and always with some new friends they had met while we had lost sight of each other.