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Adipose tissue retains an epigenetic memory of obesity after weight loss

(www.nature.com)
263 points paulpauper | 1 comments | 14 Apr 25 04:47 UTC | HN request time: 0s | source
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meindnoch ◴[17 Apr 25 12:45 UTC] No.43716014[source]▶
Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.
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phkahler ◴[17 Apr 25 13:21 UTC] No.43716434[source]▶
>> But when you lose weight, they don't apoptose

Googled for "Adipocyte apoptosis" and oh boy... It does happen, but I don't trust the AI summary. This looks like a deep rabbit hole.

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sleepyguy ◴[17 Apr 25 15:06 UTC] No.43717997[source]▶
It seems fasting causes Adipocyte apoptosis. It makes sense, there is cell death.

I lost 100 lbs fasting over 1.5 years. I did gain some weight back after stopping, but not much. Strangely, where I saw fat return was not where most of it came off.

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meindnoch ◴[17 Apr 25 18:43 UTC] No.43720643[source]▶
Yeah, but fasting is extremely unpleasant.
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sleepyguy ◴[17 Apr 25 22:09 UTC] No.43722761{3}[source]▶
You get to know yourself well after about 5 days of zero food..... :))
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1. MrGilbert ◴[18 Apr 25 05:29 UTC] No.43725286{4}[source]▶
I did that, and it helped to kickstart further weightloss. I was surprised how fast my body got rid of stored water, and how quickly I lost fat in the upper body region, primarily around my face, neck and shoulder.