Adipose tissue retains an epigenetic memory of obesity after weight loss

As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism".

It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me.

I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much of that is bro science and how much of it is grounded in reality. Maybe worth looking into more deeply if it can counteract or balance out this.

For me, sugar was the reason I couldn't lose weight. I got a CGM (continuous glucose monitor) and got my blood sugar under control, and with very little effort I lost a lot of weight.

I use 90% cacao Lindt to control my sweet tooth. 1/2 the bar has 4g of sugar, and I consume it over hours. It also has the side effect of reducing my hunger. If you eat much of 90% chocolate, it makes you feel nausea. The trick is to put a small chip in your mouth and let it melt. It's quite delicious and I've not had any sweets in 80+ days.

I thought a CGM would help me lose weight but it turned out my body is a hero at managing sugar spikes. A pint of ice cream? Back to baseline in under an hour. Big meal, no big spike, etc.

So it turns out you can still gain weight even if you don’t spike your blood sugar. At least for me.