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Adipose tissue retains an epigenetic memory of obesity after weight loss

(www.nature.com)
263 points paulpauper | 2 comments | 14 Apr 25 04:47 UTC | HN request time: 0.583s | source
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spoiler ◴[17 Apr 25 06:53 UTC] No.43713850[source]▶
As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism".

It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me.

I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much of that is bro science and how much of it is grounded in reality. Maybe worth looking into more deeply if it can counteract or balance out this.

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johnisgood ◴[17 Apr 25 14:24 UTC] No.43717325[source]▶
> It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me.

It is the exact, polar opposite for me. I cannot gain even if I eat junk all day.

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1. sharadov ◴[17 Apr 25 19:02 UTC] No.43720837[source]▶
It's hard for me to gain weight. But in my 30s, for a few months I was eating 3000 calories plus. My breakfast smoothie was about 800 calories - 2-3 scoops protein, a banana, almond butter. I gained about 5 pounds after 3 months. It was just too hard to eat that much while also eating healthy.
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2. johnisgood ◴[19 Apr 25 19:46 UTC] No.43738943[source]▶
I agree. To gain, I have to take an SSRI antidepressant to make me hungry, and then eat >4 packs of ramen (fake soup) among other things. Quite unhealthy.