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Adipose tissue retains an epigenetic memory of obesity after weight loss

(www.nature.com)
263 points paulpauper | 5 comments | 14 Apr 25 04:47 UTC | HN request time: 0.683s | source
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spoiler ◴[17 Apr 25 06:53 UTC] No.43713850[source]▶
As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism".

It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me.

I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much of that is bro science and how much of it is grounded in reality. Maybe worth looking into more deeply if it can counteract or balance out this.

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e40 ◴[17 Apr 25 13:41 UTC] No.43716696[source]▶
For me, sugar was the reason I couldn't lose weight. I got a CGM (continuous glucose monitor) and got my blood sugar under control, and with very little effort I lost a lot of weight.

I use 90% cacao Lindt to control my sweet tooth. 1/2 the bar has 4g of sugar, and I consume it over hours. It also has the side effect of reducing my hunger. If you eat much of 90% chocolate, it makes you feel nausea. The trick is to put a small chip in your mouth and let it melt. It's quite delicious and I've not had any sweets in 80+ days.

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1. nfg ◴[17 Apr 25 16:31 UTC] No.43719148[source]▶
I’d be interested to hear more here - what CGM did you buy? What was your process for monitoring?
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2. e40 ◴[17 Apr 25 16:52 UTC] No.43719410[source]▶
The Stelo. 2 for $99. Oddly, it shipped from Amazon but Amazon doesn't sell them.

The app is subpar on iOS, but if you give Apple's Health app permission, you can get more data in there. Graphs that have absolute numbers. I think they reason their app doesn't give absolute values (for historical values, they give the current value only), is because it's not a calibrated device. It can't be used to control an insulin pump, for that reason.

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3. tchock23 ◴[17 Apr 25 17:13 UTC] No.43719675[source]▶
I just completed two weeks with Lingo by Abbott. It was decent. I wish it had better integration of the data with Apple Health, but I liked the Lingo score as a way of "gamifying" it and the UX overall was decently done.
4. djmips ◴[17 Apr 25 18:45 UTC] No.43720659[source]▶
Does that imply you are paying $99 / month?
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5. e40 ◴[17 Apr 25 19:08 UTC] No.43720897{3}[source]▶
No, this was a one-time thing for me, to work out how food impacts my blood sugar. I've used 1 of the 2 I bought, and I plan to use the other in 3-4 months, to see how I react then, after 6+ months with low sugar intake.