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Adipose tissue retains an epigenetic memory of obesity after weight loss

(www.nature.com)
263 points paulpauper | 1 comments | 14 Apr 25 04:47 UTC | HN request time: 0.209s | source
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spoiler ◴[17 Apr 25 06:53 UTC] No.43713850[source]▶
As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism".

It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me.

I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much of that is bro science and how much of it is grounded in reality. Maybe worth looking into more deeply if it can counteract or balance out this.

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1. sph ◴[17 Apr 25 16:23 UTC] No.43719049[source]▶
Fat adaptation is not bro science, it is what happens when you do not consume enough carbohydrates to meet your TDEE so your mitochondria “learn” to become really efficient at burning fatty acids. It’s the whole premise behind keto/low carb. When used to our modern high-carb diets, the adaptation takes some time for genes to activate, since we eat a lot and never have long enough fasting periods to be able to quickly switch between glucose and fatty acid metabolism.