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Adipose tissue retains an epigenetic memory of obesity after weight loss

(www.nature.com)
263 points paulpauper | 1 comments | 14 Apr 25 04:47 UTC | HN request time: 0.206s | source
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meindnoch ◴[17 Apr 25 12:45 UTC] No.43716014[source]▶
Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.
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raincom ◴[17 Apr 25 14:16 UTC] No.43717202[source]▶
How do glp-1 drugs such as semaglutide, terzepatid and retatrutide impact apoptose?

"Tirzepatide promotes M1-type macrophage apoptosis and reduces inflammatory factor secretion by inhibiting ERK phosphorylation" [1]

[1] https://www.sciencedirect.com/science/article/abs/pii/S15675...

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1. cat_plus_plus ◴[17 Apr 25 14:44 UTC] No.43717649[source]▶
They tell your brain you have lots of food in your stomach, which triggers lots of behavioral and metabolic changes. This does not necessarily reverse every effect of obesity, maybe not gene expression changes described in this article. But enough to keep weight off with ongoing treatment.