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Adipose tissue retains an epigenetic memory of obesity after weight loss

(www.nature.com)
263 points paulpauper | 6 comments | 14 Apr 25 04:47 UTC | HN request time: 1.239s | source | bottom
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spoiler ◴[17 Apr 25 06:53 UTC] No.43713850[source]▶
As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism".

It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me.

I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much of that is bro science and how much of it is grounded in reality. Maybe worth looking into more deeply if it can counteract or balance out this.

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johnisgood ◴[17 Apr 25 14:24 UTC] No.43717325[source]▶
> It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me.

It is the exact, polar opposite for me. I cannot gain even if I eat junk all day.

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1. throwaway98797 ◴[17 Apr 25 14:34 UTC] No.43717464[source]▶
drink milkshakes
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2. johnisgood ◴[17 Apr 25 19:49 UTC] No.43721343[source]▶
I drink a protein shake 2 times at least, and eat lunch (chicken & rice & broccoli casserole, so forth) 2-3 times a day. I do not eat small portions either.
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3. gamblor956 ◴[17 Apr 25 21:33 UTC] No.43722468[source]▶
That only looks like about 2000 calories a day, which is the recommended caloric intake for the average sedentary adult man.

If you're trying to bulk, you need to be looking at 2500 or more calories a day, plus additional for any calories burned by exercise. (With a surplus of 1000/calories a day you'll be gaining more fat than muscle unless you're still in puberty. Sometimes that may be what you want.)

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4. johnisgood ◴[18 Apr 25 08:56 UTC] No.43726262{3}[source]▶
It just seems like I have to spend most of my day eating. :/
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5. snapcaster ◴[18 Apr 25 15:49 UTC] No.43729202{4}[source]▶
I think part of this can be solved by "hacks" the primary one being throwing olive oil on random stuff you eat. Another one is "drinking your calories". Basically all the things people tell you to do to lose weight, do the opposite
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6. johnisgood ◴[18 Apr 25 17:23 UTC] No.43730069{5}[source]▶
I get what you mean, sounds reasonable. :D