Adipose tissue retains an epigenetic memory of obesity after weight loss

Just went trough Yo-Yo. Any good strategies on how to overcome it for good?

I might consider working with a cognitive behavioral therapist. Since you’ve already lost weight, you do know (in big picture terms) how to lose/not gain weight: eat a healthy diet consistently and get regular exercise. For most people who struggle with their weight, there are emotional eating patterns or even just bad habits that are just hard to break on their own.

Of course knowledge about diet and exercise is immensely valuable, but if there are psychological factors getting in the way, it’s going to be harder to adopt a consistently healthy lifestyle.