Adipose tissue retains an epigenetic memory of obesity after weight loss

Doesn't similar happen for strength gain? People that have had larger muscles tend to have an easier time building them back up, as well.

> People that have had larger muscles tend to have an easier time building them back up, as well.

Yes, although I don't know whether that's epigenetic.

Fair. I'm now curious to know what the different forms of memory things can have. I confess I assumed they were all inter-related.

The mechanism I've heard of (heard proposed?) for skeletal muscle is that muscle cells retain the additional nuclei (myonuclei) developed during strength training, even during detraining periods. Then subsequently re-developing strength is easier because you've still got all of those nuclei.

That sounds similar to the way the fat thing was described to me, in the past. Curious how all of that relates. If anyone has a good read to dive into this, I'd be grateful!

It really lends itself to the way I model "training" for stuff. Sucks, as we want to think there are differences from rote practice and learning. But it increasingly seems that any differences there are are much softer than is often taught.