Adipose tissue retains an epigenetic memory of obesity after weight loss

Well, if the above paper is correct there is something you need to know. Epigenetic changes are caused my the methylation of DNA. So if there are epigentic chnages that are causing you to gain weight, what needs to be done is to Demethylate the DNA. This is done through Demethylase enzymes:

https://en.wikipedia.org/wiki/Demethylase

some of which have vitamin cofactors like zinc[1] and riboflavin[2].

So nutrition is important. I will let you investigate the link between zinc, riboflavin and diabetes...

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC7191051/ [2] https://www.uniprot.org/uniprotkb/O60341/entry