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Adipose tissue retains an epigenetic memory of obesity after weight loss

(www.nature.com)
263 points paulpauper | 1 comments | 14 Apr 25 04:47 UTC | HN request time: 0.208s | source
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spoiler ◴[17 Apr 25 06:53 UTC] No.43713850[source]▶
As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism".

It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me.

I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much of that is bro science and how much of it is grounded in reality. Maybe worth looking into more deeply if it can counteract or balance out this.

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1. sfjailbird ◴[17 Apr 25 11:48 UTC] No.43715412[source]▶
Insulin sensitivity is a real thing. The less sensitive to insulin you are, the more of it is produced to process a given amount of glucose. And the more insulin (anabolic) is produced, the less glucagon (catabolic) is.

In other words, low insulin sensitivity means your body remains in the feeding (fat building) state more, as opposed to fasting (fat burning).

Insulin sensitivity decreases with age, and with excessive intake of particularly simple carbs. It can be improved through fasting, certain dietary supplements, and low carb diet.

All of this is, to the best of my knowledge, not disputed or 'bro science'.