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Adipose tissue retains an epigenetic memory of obesity after weight loss

(www.nature.com)
263 points paulpauper | 5 comments | 14 Apr 25 04:47 UTC | HN request time: 0.645s | source
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paulpauper ◴[17 Apr 25 07:33 UTC] No.43714036[source]▶
The more you research/learn about obesity, the worse it is, much like smoking. One of the most depressing stats is that dieting does not get easier with time. The probability of eventually regaining all the weight eventually converges to 100%. Even if you're successful for 2 years, people still regain by year 4, 5, etc. The body never resists trying to regain the weight. GLP-1 drugs are the best hope yet.
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anon373839 ◴[17 Apr 25 08:46 UTC] No.43714393[source]▶
This is self-defeating and untrue. Many people, myself included, have kept weight off for decades. But you don’t get there by thinking of your new lifestyle as “dieting”. You need to learn to love eating healthy foods in a healthy amount, and getting exercise. Eventually you can get to a place where the old foods and habits are simply unappealing.
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1. pif ◴[17 Apr 25 08:55 UTC] No.43714432[source]▶
> in a healthy amount

That's the crux! Constant hunger starts nagging me as soon as I try. I've tried several times for several months, with nice results from the weight's points of view, but I never got to the point where my quality of life globally increased, and that was always due to the constant hunger.

I'll only retry when I'll have found a way to stop the hunger now.

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2. anon373839 ◴[17 Apr 25 10:07 UTC] No.43714837[source]▶
That’s pretty useful info! If you were feeling uncomfortably hungry beyond a short adjustment period, that makes me question if your caloric deficit was too aggressive. And/or if your diet didn’t include enough fiber and protein for satiety. (It’s also possible to be confusing other signals for hunger, like thirst, boredom, or anxiety.)

Losing weight does not have to be so hard. You can lose a lot of weight gradually over time with a small, consistent deficit. Measurement accuracy is critical, though - you will absolutely fail if you aren’t logging your food like a lab scientist.

But it is definitely possible to succeed without that constant sense of privation. In fact, if you want to succeed long-term, you HAVE to find that balance because nobody can force themselves to feel deprived indefinitely.

3. mattlondon ◴[17 Apr 25 11:58 UTC] No.43715509[source]▶
I found that sugar free hard sweets/candies helped to try and satiate some of the pangs. It's still hard, and you might end up "chain eating" like 5 or 6 of the things in a row, but I figure better that than bingeing chocolate or whatever.
4. karn97 ◴[17 Apr 25 13:53 UTC] No.43716878[source]▶
Just live with the hunger? Been starving for last 3 hours but idc really. Thats how i never went above 75kg all my life
5. AngryData ◴[18 Apr 25 09:30 UTC] No.43726404[source]▶
It doesn't help everyone but some people find it more useful to try and "enjoy" feeling hungry rather than spending as much mental effort trying to ignore it or not feel hungry. Sort of like how body builders learn to enjoy the muscle ache from heavy lifting.