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138 points pmags | 9 comments | | HN request time: 0.973s | source | bottom
1. pfdietz ◴[] No.43645260[source]
This could be a mechanism for future intracellular repair. Build little repair robots that look like mitochondria, have them insert into cells, do their magic, then leave.
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2. roman_soldier ◴[] No.43645482[source]
"do their magic" seems like it's hiding a lot of complexity.
replies(1): >>43645525 #
3. pfdietz ◴[] No.43645525[source]
Very much so.
4. epgui ◴[] No.43645981[source]
It would be much easier to package those into extracellular vesicles (exosomes or microvesicles) than into mitochondrial-like vehicles.

That has been an active area of research for a fairly long time (decades), and there are already clinical applications that have been commercialized (eg.: mRNA vaccines packaged in lipid particles).

5. spudlyo ◴[] No.43646705[source]
Or you could occasionally fast for 5-7 days to dramatically ramp up the intensity of autophagy/mitophagy in order to have your body do this for you. No robots needed. You may also discover that you like the way your brain and body operate with a different ketone/glucose energy balance.
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6. brian-armstrong ◴[] No.43648055[source]
Any significant amount of fasting is a quick way to get some very unpleasant headaches for me. No thank you.
replies(2): >>43648250 #>>43648898 #
7. spudlyo ◴[] No.43648250{3}[source]
Low blood sugar and dehydration can lead to all kinds of unpleasant side effects. When I tried to fast for the first time, I was an idiot and didn't supplement with water or electrolytes and I suffered crippling cramps.
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8. pfdietz ◴[] No.43648461{4}[source]
Low magnesium? I was having serious muscle cramps and found Mg supplements were highly effective.
9. code_biologist ◴[] No.43648898{3}[source]
Not trying to persuade you to try again, but if you ever desire to, electrolyte deficiency (particularly potassium) is a common reason that people experience headaches or cramps when fasting or starting ketogenic diets. Watch out for sugar in commercial electrolyte tablets though!