On ABZÛ we ripped out multiplayer and lots of other cruft from AActor and UPrimitiveComponent - dropping builtin overlap events, which are a kind of anti pattern anyway, not only saved RAM but cut a lot of ghost reads/writes.
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I'm having a kid-in-the-tunnel-meeting-Mean-Joe-Green-in-the-commercial moment, I just started my own game development journey about a week ago so it's neat getting to run across a full-on developer!
To stay on topic, I often thought how cool Abzu would have been with multiplayer but it's a good lesson to me that some features that might be desirable might also be a hindrance to some degree.
Okay, enough fanboying!