I think people are being a bit too negative and maybe that is because they are not used to pg's style of slogans in baby talk.
I think the gist of what pg is saying is that you should have some agency and initiative and not spend your whole life being the side character in other people's stories. This serves two purposes. First of all, it maximizes your chances of gaining wealth, power and influence. And secondly if you care to make the world a better place, it also increases your chances of having an impact.
The novelty is important, because, tautologically, if your are just copying others, you are still a side character in their story. However, I do not think this should be read as, "create the next unicorn startup". I think it is rather a principle to live by. Like for example, if you have three job offers, go for the one that allows you to build something new, rather than the one where your task is to manage a legacy product. Or for example, let's say you move to a new city and you are a bit disappointed with the activities that are available for your kids. You can either try to convince your kids to attend the available activities or you can try to organize a new after school club.