Do these live images come ready with cloud-init? A cloud-init in-memory live iso seems perfect for immutable infrastructure "anywhere"
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The trick will be in the details, as usual. User data that both does useful work... and plays nicely with immutability.
I suspect it would be more sensible to skip the gymnastics of trying to manicure something inherently resistant, and instead, lean in on reproducibility. Make it as you want it, skip the extra work.
Want another? Great - they're freely reproducible :)