Yes, it 100% caused permanent damage in me due to an interaction of the agonist with an unrelated stimulant. After years, I ultimately stumbled upon the combination of memantine+telmisartan which successfully reversed much of the damage. I still have issues with things that I cannot physically tolerate due to the leftover damage. Also, I tried other things like valproate that failed to fully reverse the damage, but caused significant permanent problems of their own. To make a long story short, use gentle safe indirect promoters for NMDA/AMPA like L-glutamine and at most phosphatidylserine, but nothing stronger or more low-level. Leave the direct agonism for the rodent studies.