I wear hard contact lenses most of the time, but I do have glasses. My glasses prescription is around +21/+23 (I would fit right in hanging out with Milhouse Van Houten or Professor Hubert J. Farnsworth), but I only wear them in emergencies because I get headaches and dizziness after 10/15 minutes of wearing them. I mostly keep 'em for the novelty of showing people just how thick my glasses are. 8)
My eyes do get tired after long screen days, resulting in blurry vision and watery eyes. I also get headaches on a somewhat frequent basis.
If that's useful at all, I'd be happy to chat more.