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The serotonin theory of depression: a systematic review of the evidence (2022)

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169 points flaxxen | 1 comments | 27 Feb 25 18:27 UTC | HN request time: 0s | source
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ieie3366 ◴[28 Feb 25 22:29 UTC] No.43212533[source]▶
Having taken SSRI for anxiety, it feels more like a second order effect. The brain is anxious, the serotonin goes in, the serotonin is not exactly "anti-anxiety" signal but "feel-good" signal.

Repeat constantly every day for months and the brain thinks, "ok we constantly have this euphoria going on, time to turn the anxiety off no need for it anymore"

This would also be why the serotonin increase is instant when starting SSRIs, but anti-anxiety effects take months and are gradual

replies(1): >>43215109 #
1. petesergeant ◴[01 Mar 25 02:41 UTC] No.43215109[source]▶
> but anti-anxiety effects take months and are gradual

Everyone is different, but the anti-anxiety effects happened almost overnight once I fixed my dosage, and I don't remember anything approaching euphoria.

Here's a paper with highlighting that shows the same:

https://pubmed.ncbi.nlm.nih.gov/31543474/#:~:text=treatment%...

Anxiety improves much before mood does.