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The serotonin theory of depression: a systematic review of the evidence (2022)

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169 points flaxxen | 2 comments | 27 Feb 25 18:27 UTC | HN request time: 0s | source
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debacle ◴[28 Feb 25 20:22 UTC] No.43209984[source]▶
For anyone interested in their own depression, some anecdotal, unscientific non-medical advice that I received from HN about a year ago:

5-HTP is a serotonin precursor that you can take in low doses to help do a lot of different things. For me, it lowered food cravings and impulsiveness, balanced out sleeping anxiety, vastly improved my gut health, and really helped with my depression. I have a positive mood about me that I haven't had since I was a teenager, and I am so vastly enjoying life today, despite the trials. Before starting a daily regimen of 5-HTP, I was worried that I might one day lose myself to suicide. Now I treasure every day. Truly changed my life. Maybe it will change yours.

Again this is completely anecdotal, unscientific non-medical advice.

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1. xlbuttplug2 ◴[28 Feb 25 21:34 UTC] No.43211536[source]▶
Just a reminder not to impulse buy without first doing some research. IIRC serotonin syndrome is a risk, especially if already on antidepressants.

Some things to note in case you decide to go ahead anyway: https://www.reddit.com/r/Nootropics/comments/28489u/comment/...

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2. johnisgood ◴[28 Feb 25 21:56 UTC] No.43211975[source]▶
Serotonin syndrome is a low risk, I believe. If it is as common as they make it out to be, I should have had it a million times, unless I am somehow the exception.